Biomedical Applications of Nanotechnology

Universidad Carlos III de Madrid

Course Description

  • Course Name

    Biomedical Applications of Nanotechnology

  • Host University

    Universidad Carlos III de Madrid

  • Location

    Madrid, Spain

  • Area of Study

    Biomedical Engineering, Nanosystems Engineering

  • Language Level

    Taught In English

  • Prerequisites

    Students are strongly advised to have completed the subjects Chemistry, Materials Science and Engineering and Introduction to Biomaterials.

  • Course Level Recommendations

    Upper

    ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels.

    Hours & Credits

  • ECTS Credits

    6
  • Recommended U.S. Semester Credits
    3
  • Recommended U.S. Quarter Units
    4
  • Overview

    Biomedical applications of nanotechnology (257 - 15565)
    Study: Bachelor in Biomedical Engineering
    Semester 2/Spring Semester
    4th Year Course/Upper Division

    Students are Expected to have completed:

    Students are strongly advised to have completed the subjects Chemistry, Materials Science and Engineering and Introduction to Biomaterials.

    Compentences and Skills that will be Acquired and Learning Results:

    Through lectures, paper reviews and practices, students will be introduced to the vast field of nanotechnology for biomedical applications.
    The course will focus on the use of nanoparticles in medical imaging and therapy.
    Students will become familiar with the main techniques employed to synthesize and characterize most common nanomaterials.
    The global aim will be to get an idea of what makes nano-world different and which are the main applications in Biomedical Engineering.

    Description of Contents: Course Description

    1.- INTRODUCTION TO NANOTECHNOLOGY
    Definitions
    Physicochemical features
    Nanoparticle-cell interactions
    2.- CHARACTERIZATION TECHNIQUES
    Transmission and Scanning Electronic Microscopy
    Dynamic Light Scattering
    Atomic Force Microscopy
    UV-vis spectroscopy
    Infrared spectroscopy
    3.- BIOCONJUGATION TECHNIQUES
    Introduction to Organic Chemistry
    Organic Chemistry Synthesis
    Proteins
    Antibodies
    4.- ORGANIC NANOMATERIALS
    Liposomes
    Dendrimers
    Polimers
    Carbon nanotubes
    5.- INORGANIC NANOPARTICLES
    Superparamagnetic Nanoparticles
    Gold Nanoparticles
    Fluorescent Nanomaterials
    6.- MULTIFUNCTIONAL PROBES
    Theranostics
    MRI/Optical
    PET/MRI
    7.- BIOMEDICAL APPLICATIONS
    Molecular imaging
    Drug and gene delivery
    Oncology
    Cardiovascular diseases
    Pulmonary diseases
    8.- NANOTOXICOLOGY
    9.- CONCLUSIONS AND FUTURE

    Lab practices
    We will undertake 4 lab practices, 3 at UC3M labs and one in the visit to Centro Nacional de Investigaciones Cardiovasculares. The dates will be announced early in the course with a similar time schedule than regular classes.

    Preparation of liposomes (UC3M)
    Synthesis of gold nanomaterials (UC3M)
    Synthesis of iron oxide nanomaterials and characterisation (CNIC)
    Gold nanoparticles-based sensors (UC3M)

    Learning Activities and Methodology:

    Each section of the program will be divided into lectures and practical sessions/seminars.
    Most of the practical sessions will take place at the Laboratories in the UC3M but some of them may require visits to Hospital Gregorio Marañón and Centro Nacional de Investigaciones Cardiovasculares.

    Assessment System:

    Grading will be based on continuous evaluation and a final exam covering the whole subject, including invited lectures and seminars. Help sessions and tutorial classes will be held prior to the final exam upon students request.Attendance to lectures and seminars is not compulsory. However, failure to attend any test or submit the exercises before the deadline will result in a mark of 0 in the corresponding continuous evaluation block (see below).

    GRADING: Total score: 10 pointsContinuous evaluation: 5 points out of 10 Final exam: 5 points out of 10
    CONTINUOUS EVALUATION: It accounts for up to 50% of the final score of the subject (5 points of the TOTAL SCORE), and includes two components:1) Three tests: 3 points of THE TOTAL SCORE. These tests will take place mostly during lectures and will be announced at least one week in advance.
    2) 2 point of THE TOTAL SCORE for a scientific papers presentations, lab practices and exercises

    FINAL EXAM: The final exam will cover the whole subject, including invited lectures and seminars, and will account for the 50 % of the final score (5 points of the TOTAL SCORE). The minimum score in the final exam to pass the subject is 4 over 10, notwithstanding the mark obtained in continuous evaluation.

    EXTRAORDINARY EXAM: The mark for students attending any extraordinary examination will be either a) 100% extraordinary exam mark, or b) 50% extraordinary exam mark and 50% continuous evaluation if itis available in the same course.

    ACADEMIC CONDUCT: Unless specified, all exams will be closed-book, closed-notes, no PC or mobile phone, or anything else other than a writing implement and the exam itself. Plagiarism, cheating or other acts of academic dishonesty will not be tolerated. Any infractions whatever will result in a failing grade.

    % end-of-term-examination: 50 % of continuous assessment (assigments, laboratory, practicals...)

    Basic Bibliography:

    Greg T. Hermanson (Second Edition). Bioconjugate Techniques. Elsevier Inc.. 2008
    Paras N. Prasad. Introduction to Nanomedicine and Nanobioengineering: Transforming Healthcare with Nanotechnology. John Wiley and Sons. 2012

    Additional Bibliography:

    Mauro Ferrari, Ph.D., Editor-in-Chief.. BioMEMS and Biomedical Nanotechnology. Vol. 1 Biological and Biomedical Nanotechnology. Springer. 2006
    Rajaventhan Srirajaskanthan, M.D.,Victor R. Preedy, Ph.D. Nanomedicine and Cancer. CRC Press. 2012
    Vijay K. Varadan,LinFeng Chen,Jining Xie. Nanomedicine: Design and Applications of Magnetic Nanomaterials, Nanosensors . John Wiley and Sons. 2008

Course Disclaimer

Courses and course hours of instruction are subject to change.

ECTS (European Credit Transfer and Accumulation System) credits are converted to semester credits/quarter units differently among U.S. universities. Students should confirm the conversion scale used at their home university when determining credit transfer.