Molecular and Microbial Genetics

University of Otago

Course Description

  • Course Name

    Molecular and Microbial Genetics

  • Host University

    University of Otago

  • Location

    Dunedin, New Zealand

  • Area of Study

    Genetics, Microbiology, Molecular Biology

  • Language Level

    Taught In English

  • Prerequisites

    CELS 191 and CHEM 191 and 36 further points

  • Course Level Recommendations

    Upper

    ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels.

    Hours & Credits

  • Credit Points

    18
  • Recommended U.S. Semester Credits
    3 - 4
  • Recommended U.S. Quarter Units
    4 - 6
  • Overview

    Mutations; genetic analysis in bacteria; mobile genetic elements; genetic analysis of regulatory circuits; DNA cloning and sequencing in genetic analysis; comparative microbial genomics; genetics and evolution of viruses of eukaryotes.
    GENE 221 provides foundation material on molecular and microbial genetics. Topics include mutation, gene transfer and genetic analysis in bacteria, DNA cloning, and comparative genomics of bacteria, fungi and the HIV retrovirus. Discoveries and methodologies in microbial genetics underlie all aspects of modern biology and therefore this paper is directly relevant for students with an interest in any of the biological sciences. The lecture course is complemented by a laboratory course that includes four experiments that together give hands-on experience of many of the genetic principles that are discussed in the lectures.

    Course Structure
    The lecture course is divided into 6 modules:
    -Mutations - the basis of geneticsGene transfer and genetic analysis in bacteria
    -Genetic analysis of regulatory circuits
    -Comparative microbial genomics and evolution
    -Comparative fungal genomics
    -Genetics of HIV

    The lecture course is complemented by a laboratory course, which provides training in relevant genetic methods and data analysis, including mutagen detection using the Ames test, gene mapping by conjugation, transposon mutagenesis and DNA cloning using a plasmid vector.

    Learning Outcomes
    The broad objectives of GENE 221 are to understand:
    -The molecular basis and significance of mutation
    -Classical genetics of bacteria
    -The genetic approaches used in analysing gene regulation in bacteria
    -DNA cloning as a tool for genetic analysis
    -The use of comparative genomics in understanding the evolution of bacteria, yeast, other fungi and the HIV retrovirus

    Textbooks
    The recommended text book for GENE 221 is:
    Introduction to Genetic Analysis (Griffiths, Wessler, Lewontin, Gelbart, Suzuki and Miller), 10th Edition. The 9th Edition of this book is also satisfactory if you have access to a copy.

Course Disclaimer

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Please note that some courses with locals have recommended prerequisite courses. It is the student's responsibility to consult any recommended prerequisites prior to enrolling in their course.